Late 20th to early 21st centuries: Terran nation-states fight “brushfire wars” by proxy; early eugenics and robotics efforts end in disaster; humanity nearly self-destructs.
2063: Zephram Cochrane’s faster-than-light experiments lead to open and official First Contact with Vulcans (First Contact, 1996).
22nd century: Terrans unite and rebuild, begin colonizing Mars.
2151 to 2155: Capt. Jonathan Archer helps found the United Federation of Planets (Enterprise, 2001 to 2005).
2156 to 2160: First Earth-Romulan War; Neutral Zone established.
2233 to 2259: One alternate universe splits off (Kelvin timeline: 2009 Star Trek, 2013 Into Darkness, 2016 Beyond).
2245 to 2265: The Constitution-class cruiser U.S.S. Enterprise,NCC 1701, under the command of Capt. Robert April and Capt. Christopher Pike (Discovery, 2018 to 2020, Strange New Worlds, 2021).
2266 to 2269: The first voyages of the Enterprise under Capt. James T. Kirk in the Alpha and Beta quadrants (original Star Trek television series, 1966 to 1969). The U.S.S. Rustam goes on missions.
2269 to 2270: The remainder of the Enterprise ’s first five-year mission (The Animated Series, 1973 to 1974); journeys of the U.S.S. Eagle,NCC 956 (SUNY-Binghamton, 1988) and Constitution (Virginia, 1993).
2273: The V’ger incident (The Motion Picture, 1979).
2285 to 2286: The command crew of the refitted Enterprise defeats Khan Noonien Singh and Klingons and goes rogue but saves Earth (The Wrath of Khan, Search for Spock, Voyage Home, 1982 to 1986).
2287 to 2293: The NCC 1701-A is retired after several successful missions (The Final Frontier, Undiscovered Country, Generations, 1989 to 1994).
2344: The Ambassador-class NCC 1701-C, under Capt. Rachael Garrett, is destroyed, leading to renewed peace talks with the Klingons (TNG “Yesterday’s Enterprise”).
2355 to 2359: First Federation-Cardassian War. Ferengi traders challenge the Federation, as Jean-Luc Picard takes command of the U.S.S. Stargazer.
2364 to 2370: The Galaxy-class U.S.S. Enterprise,NCC 1701-D, conducts diplomacy under Capt. Jean-Luc Picard (The Next Generation, 1987 to 1994). The U.S.S. Venture thwarts Orion pirates and rescues personnel at Xerxes Station (2d20 Star Trek Adventures, Boston, 2017)
2367: The Borg destroy much of Starfleet at the Battle of Wolf 359.
2369 to 2375: The Federation first explores the Gamma Quadrant and is involved in the Klingon Civil War and the Dominion War (Deep Space Nine, 1993 to 1999).
2371 to 2379: The Sovereign class NCC 1701-E fights the Borg and Remans, among others (Generations, First Contact, Insurrection, Nemesis, 1994 to 2002); the Voyager is stranded in the Delta Quadrant (1995 to 2001); first five-year mission of the Excelsior class U.S.S. Tempest,NCC 2094-B, under “Capt. Tzu Tien Lung” (Virginia, 1994 to 1997).
2380 to 2409: The Alpha and Beta quadrants attempt to rebuild after several core worlds are badly damaged and interstellar states fragment (Picard, 2020; Titan novels and various fan films).
2409 to 2417: Starfleet resumes expansion after another war with the Klingons and Orions, as well as Undine incursions (Star Trek OnlineMMO, 2010 to present).
1 May 2412 A.D./C.E. (Stardate 889332.7): The Curiosity-class U.S.S. Sacagawea begins exploring the Alpha Quadrant (FATE “Star Trek: Restoration” telecom crew, 2020).
2418 (Stardate 95248): The refitted Ambassador class U.S.S. Rotha,NCC 1993-C, begins its first five-year mission of defense, exploration, and diplomacy (Boston D20/FATEscenarios, 2014).